Buffers play a significant role in biopharmaceutical manufacturing. Typically representing a major component by volume used in downstream processing steps, buffer preparation constitutes a significant proportion of a facility‘s footprint, labor requirements and equipment cost.
There are multiple ways buffers can be supplied; an established way to manufacture buffers in-house is with the use of USP or WFI grade water to hydrate powders in stainless steel or single-use tanks.
While this method is established and ideal for large volumes, these operations need significant infrastructure. This includes warehouse space for holding raw materials prior to use and a weighing and dispensing area for raw materials.
Therefore, looking at the cost and complexity of in-house buffer preparation, the adoption of hydrated, premade liquid, buffers and buffer concentrates can be a cost-, time- and resource-saving alternative.
Contact us to discuss different alternative buffer management strategies that can be applied as either a stand-alone solution or in combination to achieve workflow improvements, depending on the size of your operations and facility.
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Innovative new technologies like single use powder packaging and in-line dilution can help reduce facility footprint, labor hours and overall cost-of-goods